Decreased MiR-17 in glioma cells increased cell viability and migration by increasing the expression of Cyclin D1, p-Akt and Akt.
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| Abstract | :
The activating mutations of micro RNA (miR)-17 have been revealed in tumors such as human non-Hodgkin's lymphoma and T cell leukemia. However, it is unclear about the role of miR-17 in glioma cells. The current study aimed to investigate effects of miR-17 mimics or inhibitor on the viability and migration of rat glioma C6 cells, and explore possible mechanisms. |
| Year of Publication | :
0
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| Journal | :
PloS one
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| Volume | :
13
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| Issue | :
1
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| Number of Pages | :
e0190515
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| Date Published | :
2018
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| URL | :
http://dx.plos.org/10.1371/journal.pone.0190515
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| DOI | :
10.1371/journal.pone.0190515
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| Short Title | :
PLoS One
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