Challenges associated with the targeted delivery of gelonin to claudin-expressing cancer cells with the use of activatable cell penetrating peptides to enhance potency.
| Author | |
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| Abstract | :
Treatment of tumors with macromolecular toxins directed to cytoplasmic targets requires selective endocytosis followed by release of intact toxin from the endosomal/lysosomal compartment. The latter step remains a particular challenge. Claudins 3 and 4 are tight junction proteins that are over-expressed in many types of tumors. This study utilized the C-terminal 30 amino acid fragment of C. perfringens enterotoxin (CPE), which binds to claudins 3 and 4, to deliver a toxin in the form of recombinant gelonin (rGel) to the cytoplasm of the human ovarian carcinoma cell line 2008. |
| Year of Publication | :
1969
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| Journal | :
BMC cancer
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| Volume | :
11
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| Number of Pages | :
61
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| Date Published | :
2011 Feb 8
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| URL | :
http://www.biomedcentral.com/1471-2407/11/61
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| DOI | :
10.1186/1471-2407-11-61
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| Short Title | :
Challenges associated with the targeted delivery of gelonin to c
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