Efficacy and safety of longer-term administration of evolocumab (AMG 145) in patients with hypercholesterolemia: 52-week results from the Open-Label Study of Long-Term Evaluation Against LDL-C (OSLER) randomized trial.
| Author | |
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| Abstract | :
Evolocumab (AMG 145), a monoclonal antibody against proprotein convertase subtilisin/kexin type 9 (PCSK9), significantly reduced low-density lipoprotein cholesterol (LDL-C) in phase 2 studies of 12 weeks' duration. The longer-term efficacy and safety of PCSK9 inhibition remain undefined. |
| Year of Publication | :
2014
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| Journal | :
Circulation
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| Volume | :
129
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| Issue | :
2
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| Number of Pages | :
234-43
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| Date Published | :
2014
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| ISSN Number | :
0009-7322
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| URL | :
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.113.007012?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
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| DOI | :
10.1161/CIRCULATIONAHA.113.007012
|
| Short Title | :
Circulation
|
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