Cardiomyocyte-specific overexpression of syndecan-4 in mice results in activation of calcineurin-NFAT signalling and exacerbated cardiac hypertrophy.
| Author | |
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| Abstract | :
Cardiomyocyte hypertrophy is a hallmark of cardiac dysfunction in patients with aortic stenosis (AS), and can be triggered by left ventricular (LV) pressure overload in mice by aortic banding (AB). Syndecan-4 is a transmembrane heparan sulphate proteoglycan which is found increased in the myocardium of AS patients and AB mice. The role of syndecan-4 in cardiomyocyte hypertrophy is not well understood. |
| Year of Publication | :
2022
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| Journal | :
Molecular biology reports
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| Date Published | :
2022
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| ISSN Number | :
0301-4851
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| URL | :
https://doi.org/10.1007/s11033-022-07985-y
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| DOI | :
10.1007/s11033-022-07985-y
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| Short Title | :
Mol Biol Rep
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