Effects of the dual orexin receptor antagonist DORA-22 on sleep in 5XFAD mice.
| Author | |
|---|---|
| Abstract | :
Sleep disruption is a characteristic of Alzheimer's disease (AD) that may exacerbate disease progression. This study tested whether a dual orexin receptor antagonist (DORA) would enhance sleep and attenuate neuropathology, neuroinflammation, and cognitive deficits in an AD-relevant mouse model, 5XFAD. |
| Year of Publication | :
0
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| Journal | :
Alzheimer's & dementia (New York, N. Y.)
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| Volume | :
5
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| Number of Pages | :
70-80
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| Date Published | :
2019
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| DOI | :
10.1016/j.trci.2019.01.003
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| Short Title | :
Alzheimers Dement (N Y)
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