Effects of posaconazole (a strong CYP3A4 inhibitor), two new tablet formulations, and food on the pharmacokinetics of idasanutlin, an MDM2 antagonist, in patients with advanced solid tumors.
| Author | |
|---|---|
| Abstract | :
Idasanutlin, a selective small-molecule MDM2 antagonist in phase 3 testing for refractory/relapsed AML, is a non-genotoxic oral p53 activator. To optimize its dosing conditions, a number of clinical pharmacology characteristics were examined in this multi-center trial in patients with advanced solid tumors. |
| Year of Publication | :
2018
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| Journal | :
Cancer chemotherapy and pharmacology
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| Date Published | :
2018
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| ISSN Number | :
0344-5704
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| URL | :
https://dx.doi.org/10.1007/s00280-018-3521-z
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| DOI | :
10.1007/s00280-018-3521-z
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| Short Title | :
Cancer Chemother Pharmacol
|
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